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Cape Girardeau, Missouri
My 10 Favorite Restaurants in Cape Girardeau, MO

My 10 Favorite Restaurants in Cape Girardeau, MO

TLDR (too long; didn’t read): For a unique blend of smoked meats and bourbon cocktails, you can’t go wrong with Mary Jane Bourbon + Smokehouse. From the Pulled Pork Mac and Cheese to the Trinity Special, expect chef-inspired dishes in a lively two-story setting.

For those keen on plant-based dishes, Trio Restaurant is your spot. Their 100% plant-based menu, featuring delights like Jackfruit BBQ tacos and Macho Nachos, provides a modern twist to classic comfort food in a serene atmosphere.

about matthew
Updated August 25, 2023
Hey there! I'm Matthew, I'm a passionate traveler who loves to explore the US with my family. I'm excited to share my experiences and tips on how to make the most of your trips while traveling in the US.
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1. Port Cape Girardeau Restaurant and Lounge

Bar & Barbecue, Mid-Range Meals, Alcohol Friendly

Port Cape Girardeau Restaurant and Lounge

Port Cape Girardeau Restaurant and Lounge is a must-visit destination for barbeque lovers. With a reputation for serving the finest barbeque in the area, this restaurant takes pride in using a combination of hickory wood and charcoal to create a unique flavor. The meats are slow-cooked for up to 12 hours in the pit, ensuring that they are tender enough to fall off the bone when gently pulled – hence the term “pulled” barbeque.

The restaurant believes that barbeque is an art form and has perfected it over the years. The ribs are smoked for an average of seven hours to achieve the right color and smoke penetration for their standards. With a passion for this traditional method of cooking, the restaurant invites you to enjoy their barbeque and experience the taste of authentic, slow-cooked meat.

Why I Recommend

Port Cape Girardeau Restaurant and Lounge is highly recommended for its excellent food, generous portions, and remarkable service. Visitors can relish in a range of delectable offerings, from enormous and flavorful Po Boys paired with fresh port chips, to the perfectly balanced Blackberry Cobbler. Beyond its culinary appeal, the venue also boasts a lively music scene and has a historic charm that adds to the overall dining experience.

See what people are saying in their Google Reviews.

Contact Information

Phone Number: (573) 334-0954

Address: 19 N Water St, Cape Girardeau, MO 63701

Service options: Dine-in · Curbside pickup · No-contact delivery

2. Mary Jane Bourbon + Smokehouse

Smokehouse, Mid-Range Meals, Alcohol Friendly

Mary Jane bourbon and smokehouse

If you’re looking for a delicious meal paired with a unique drink experience, Mary Jane bourbon + smokehouse is a great option. Located in Downtown Cape Girardeau, Missouri, this restaurant serves up chef-inspired smoked meat dishes alongside hand-crafted bourbon cocktails. Named after the owner’s grandmother, Mary Jane, the restaurant’s philosophy centers around generous hospitality, high quality, and great service.

At Mary Jane bourbon + smokehouse, the focus is on using the freshest ingredients and buying local when possible to create a menu that is both delicious and sustainable. Whether you’re looking for a quick lunch or a night out with friends, this restaurant offers a cozy neighborhood feel and live music to make your experience even more enjoyable. Come enjoy the mouth-watering flavors, great cocktails, and friendly atmosphere that Mary Jane bourbon + smokehouse has to offer.

Why I Recommend

Mary Jane is a fantastic choice for anyone seeking a delightful casual dining experience, marked by a range of hearty dishes such as the generous trinity special and the sumptuous Pulled Pork Mac and Cheese doused in a sweet and spicy BBQ sauce. The ambiance mirrors that of a beachside bourbon bar, spread across two floors and buzzing with an energetic atmosphere. Patrons can expect friendly and insightful service, making it an ideal spot for larger groups and celebrations.

See what people are saying in their Google Reviews.

Contact Information

Phone Number:  (573) 334-6279

Address: 1107 Broadway St, Cape Girardeau, MO 63701

Service options: Dine-in · Curbside pickup · Delivery

3. Gabriel’s Food + Wine

Italian, Mid-Range Meal, Alcohol Friendly

Gabriels Food and Wine

Gabriel’s Food + Wine is a renowned gourmet Italian restaurant located in Cape Girardeau, Missouri. Founded by Gabriele, a Milan graduate in Marketing Management, this restaurant offers a unique blend of world-class Italian cuisine and exceptional hospitality.

Gabriele’s passion for food and travel has led him to master the art of fine dining, working at some of the world’s most prestigious restaurants and luxury hotels. His experiences have helped him develop a distinct service concept that emphasizes the value of hospitality and the use of the best ingredients in his restaurant.

At Gabriel’s Food + Wine, guests can expect to indulge in an exquisite Italian culinary experience that reflects the founder’s dedication to quality, authenticity, and innovation. The restaurant offers a warm and inviting atmosphere, making it the perfect destination for a romantic night out, family dinner, or special occasion.

Why I Recommend

The heavenly mushroom and squash lasagna or the rich and flavorful duck fettuccine are perfect representations of the culinary excellence offered, with no need for additional seasoning. The restaurant further sets itself apart with its array of delicious appetizers, such as the polenta fries and bruschetta, complemented by an extensive wine list, made all the more appealing by the insightful staff offering excellent recommendations.

See what people are saying in their Google Reviews.

Contact Information

Phone Number: (573) 803-2449

Address: 127 Main St, Cape Girardeau, MO 63701

Service options: Dine-in · Takeout · No-contact delivery

4. 36 Restaurant & Bar

Fine Dining, Luxury Dining, Alcohol Friendly

36 Restaurant and Bar

36 Restaurant & Bar is a popular eatery located in the heart of historic downtown Cape Girardeau. The restaurant is known for its contemporary American cuisine, which is prepared with fresh and locally sourced ingredients. The menu features a wide range of options, from classic comfort food to more adventurous dishes, ensuring that there is something to suit every taste.

In addition to the delicious food, 36 Restaurant & Bar is also known for its stylish and inviting atmosphere. The interior is modern and chic, with sleek furnishings and warm lighting creating a welcoming ambiance. Whether you’re looking to enjoy a casual meal with friends or a romantic dinner for two, this restaurant is the perfect choice. With its prime location and top-notch cuisine, 36 Restaurant & Bar is a must-visit destination for anyone visiting Cape Girardeau.

Why I Recommend

36 Restaurant & Bar is a sophisticated dining destination, serving meticulously cooked dishes such as the perfect steak, in a classy and chic atmosphere. The commitment to top-notch service, with attentive and respectful staff, enhances the overall dining experience and contributes to its status as a favorite amongst locals and newcomers alike. This establishment is the perfect spot for special occasions or for those seeking a superior dining experience, complete with an open bar that serves excellent espresso martinis.

See what people are saying in their Google Reviews.

Contact Information

Phone Number: (573) 803-2333

Address: 36 Main St, Cape Girardeau, MO 63701

Service options: Dine-in · Takeout

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5. The Southerner

Bar & Grill, Mid-Range Meals, Alcohol Friendly

The Southerner

Welcome to The Southerner, a charming and inviting eatery that offers a taste of the South like no other. Located in the heart of town, The Southerner is a family-owned business that has been serving up authentic Southern cuisine for years. Every day, the talented chefs at The Southerner prepare dishes from scratch, using only the freshest and finest ingredients available.

With a menu that is inspired by traditional family recipes and a passion for all things Southern, The Southerner is a must-visit for anyone looking to indulge in some delicious and hearty Southern fare. From classic dishes like fried chicken and shrimp and grits to more modern twists like pimento cheeseburgers and avocado toast, there’s something for everyone at The Southerner.

So why not stop by and experience the warm hospitality and mouth-watering cuisine at The Southerner for yourself? And if you’re curious to learn more about the inspiration behind their dishes, be sure to check out their blog and follow them on Facebook for behind-the-scenes stories and updates.

Why I Recommend

The Southerner offers an upscale dining experience that pleasantly surprises with its exceptional, locally-inspired southern cuisine. A must-try recommendation is the delicious pork chop and gouda mac and cheese, each considered a standout dish on a menu that leaves you hard-pressed to find something not to enjoy. The establishment offers superb service, courtesy of a fantastic, attentive staff that gives excellent recommendations, complemented by a range of phenomenal drinks. Be sure to make a reservation for larger groups or peak times, but rest assured, any wait is worth the delectable dining experience you’ll encounter.

See what people are saying in their Google Reviews.

Contact Information

Phone Number:  (573) 708-6530

Address: 3359 Percy Dr, Cape Girardeau, MO 63701

Service options: Dine-in · Takeout

6. Trio Restaurant

Plant-Based, Mid-Range Meals, Alcohol-Free

Trio Restaurant Cape Girardeau MO

Tucked away in the quaint town of Cape Girardeau, Missouri, Trio Restaurant offers a unique experience for plant-based food lovers. As a 100% plant-based restaurant, Trio celebrates the vibrant colors, flavors, and benefits of the plant kingdom. Passionate about providing a modern twist to classic comfort food, the menu offers an array of mouth-watering dishes. From burgers and sandwiches to salads, tacos, and more, each dish is made with fresh and locally-sourced ingredients. 

The atmosphere at Trio is warm and inviting, with an ambiance that encourages guests to enjoy the moment. The friendly staff is always available to answer any questions about the food or the restaurant itself. Whether you’re looking for a quick bite or a relaxing meal with friends, Trio has something for everyone. Come see why Trio Restaurant is quickly becoming one of the most popular plant-based restaurants in Cape Girardeau.

Why I Recommend

Trio Restaurant is a superb choice for those seeking a delightful array of vegan and vegetarian options in a relaxing environment. The restaurant offers diverse menu choices, including crowd favorites such as the Macho Nachos, Jackfruit BBQ tacos, and a chick’n sandwich that are served hot, fresh, and promptly. Not only does Trio cater to dietary restrictions like dairy-free, but it also provides an enticing kids’ menu, making it a top pick for families, and the ample street parking adds to the overall convenience.

See what people are saying in their Google Reviews.

Contact Information

Phone Number: (573) 803-3095

Address: 1027 Broadway Cape Girardeau, MO 63701

Service options: Dine-in · Takeout · Delivery

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7. El Sol

Mexican, Mid-Range Meals, Alcohol Friendly

El Sol

El Sol Mexican Restaurant is the perfect place to enjoy delicious and authentic Mexican cuisine. Located in the heart of the city, El Sol is a family owned restaurant that has been serving up fresh and flavorful Mexican dishes since 1992. The menu features a variety of authentic Mexican dishes such as tacos, enchiladas, fajitas and burritos, all made with fresh ingredients and traditional spices. The restaurant also serves up classic Mexican desserts like flan and churros.

At El Sol, you can enjoy the warm and friendly atmosphere while indulging in the delectable flavors of Mexico. With a wide variety of dishes to choose from, El Sol is sure to please everyone in your party. The restaurant also features a full bar with an extensive selection of tequilas and other spirits. So come and experience the true taste of Mexico at El Sol Mexican Restaurant.

Why I Recommend

El Sol provides an excellent experience with its vibrant selection of Mexican cuisine, including standout items like their top-rated salsa and enticing $1 Taco Tuesday deal. The restaurant continually innovates, as shown by the recently added $2 street tacos. Additionally, El Sol offers an accommodating service with options for catering large orders at short notice, and with an inclusive menu catering to dietary restrictions like gluten-free, vegetarian, and low-carb options. Their delicious margaritas and creamy white cheese dip make it a place worth visiting for a gratifying dining experience.

See what people are saying in their Google Reviews.

Contact Information

Phone Number: (573) 803-2775

Address: 1105 Broadway St, Cape Girardeau, MO 63701

Service options: Dine-in · Curbside pickup · No-contact delivery

8. Sedona Bistro

Bistro, Mid-Range Meals, Alcohol Friendly

Sedona Bistro

Sedona Bistro is a restaurant that embodies the spirit of community and family. Their menu features a selection of family-favorite recipes, prepared with fresh ingredients and attention to detail. Each dish is made with the same care and quality that you would expect at a home-cooked meal.

At Sedona, the idea of the family table is the inspiration behind the brand. The restaurant is steeped in love, rooted in tradition, and charmingly imperfect, just like family. Whether you’re dining alone or with loved ones, you’ll feel like part of the Sedona family at every meal. So come join them at the table and experience the warmth and hospitality that Sedona Bistro has to offer.

Why I Recommend

Sedona Bistro is an exceptional dining destination known for its flavorful dishes, such as the French dip with perfectly seasoned fries and appetizing white chocolate cheesecake. This culinary haven also showcases a well-curated selection of beers from local and popular breweries, ensuring an enjoyable experience for beverage enthusiasts. With specialties like the superbly seasoned potato skins, slightly sweet Reuben, and the irresistible Pretzel Knots filled with pimento cheese and served with a delightful beer cheese dip, Sedona Bistro offers a mouth-watering array of dishes to satisfy a variety of palates.

See what people are saying in their Google Reviews.

Contact Information

Phone Number: (573) 803-5000

Address: 1812 Carondelet Dr #101, Cape Girardeau, MO 63701

Service options: Dine-in · Curbside pickup · No-contact delivery

9. Chan’s Restaurant

Chinese, Budget Friendly, Alcohol Friendly

Chans Restaurant

Chan’s Restaurant is a popular eatery located at 1159 North Kings Highway Street, Cape Girardeau, MO 6370. Known for its delicious cuisine and welcoming atmosphere, this restaurant is a must-visit destination for foodies and travelers alike.

With a focus on quality ingredients and authentic flavors, Chan’s Restaurant offers a diverse menu that caters to a range of tastes and preferences. Whether you’re in the mood for traditional Asian cuisine or more contemporary dishes, you’re sure to find something that hits the spot.

So if you’re looking for a memorable dining experience in Cape Girardeau, be sure to check out Chan’s Restaurant. With its excellent food and friendly service, this restaurant is sure to leave a lasting impression.

Why I Recommend

Chan’s Restaurant is recognized for its serene and peaceful ambiance, complemented by warm and efficient service. The diverse menu features impeccably executed Chinese classics, such as their distinguished egg drop soup, delightful fried brown rice, and sweet and sour chicken featuring fresh pineapple. The restaurant’s attention to detail is exemplified in the quality of their dishes, such as the Mei Fun that stands out for its non-greasy preparation and well-roasted pork. With unique touches like origami money decor adding to its charm, Chan’s restaurant assures an unforgettable dining experience.

See what people are saying in their Google Reviews.

Contact Information

Phone Number: (573) 651-4466

Address: 1159 North Kings Highway Street, Cape Girardeau, MO 6370

Service options: Dine-in · Takeout · No-contact delivery

10. Ciao

Italian, Mid-Range Meals, Alcohol Friendly

Ciao

Ciao Ristorante + Enoteca is a must-visit business located in the heart of Cape Girardeau. Situated on the 1st floor of the Banterra Centre, this Italian establishment boasts a library filled with exotic wines from Italy and around the world, including some familiar favorites from closer to home. The Enoteca is a true Italian tradition, designed to be a social experience that is best shared among friends.

At Ciao, the emphasis is on creating a relaxed and warm environment that encourages social interaction. The ristorante aims to combine the traditional Italian spirit of fun and friendship with an authentic and delicious dining experience. Whether you are looking to enjoy a glass of wine or indulge in some fantastic Italian cuisine, Ciao has something to offer. Reservations are welcomed but not required, and the business is open Tuesday through Saturday. Overall, Ciao Ristorante + Enoteca is the perfect place to unwind and enjoy the best of Italian food and wine.

Why I Recommend

Ciao offers an impeccable evening experience perfect for date nights or special occasions. The staff and owners ensure friendly and top-tier service, complimenting the outstanding quality of food offered. While the restaurant maintains a relaxing atmosphere with upscale decor, the fine Italian dining experience might feel somewhat out of sync with their choice of background music. Despite being on the pricier side, many patrons still consider it a worthy investment due to the high culinary standard and exceptional service.

See what people are saying in their Google Reviews.

Contact Information

Phone Number: (573) 332-8884
Address: 1650 North Kingshighway #102, Cape Girardeau, MO 63701

Service options: Dine-in · Takeout

About the Author
about matthew
Matthew Mellinger
Hey there! I'm Matthew, and I'm a passionate traveler who loves to explore the US with my family of four. I'm excited to share my experiences and tips on how to make the most of your trips while traveling in the US.

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